Revealing fibrosis in the atria

ADAS-AF is a software application designed to characterize the tissue of the Left Atrium (LA). It is intended for the electrophysiologist to help understand the substrate of the LA to help in ablation procedures, before and during the intervention, using the information provided by Late Gadolinium Enhancement (LGE) 3D MRI.

What it does

ADAS-AF provides tools for defining the shape of the LA from 3D LGE MRI DICOM data. It then automatically computes the IIR value of the atrial wall and quantifies the fibrosis, the atrial volume and the Sphericity (according to J Cardiovasc Electrophysiol. 2013 Jul;24(7):752-9). It also allows exporting the segmented LA 3D shape and associated fibrosis into formats compatible with EP navigation systems.

The interface

Interface to verify the relationship between the 3D Left Atrium and its corresponding MRI (image Courtesy of Leipzig Heart Center, Interventional CMR Unit, Dept. of Rhythmology, Ingo Paetsch/Prof. G. Hindricks).

Left Atrium Fibrosis Map

Left Atrium with Fibrosis Mapped using the IIR method.

Software Information

ADAS-AF is a standalone post-processing software solution is intended for the electrophysiologist to help understand the substrate of the LA to help in ablation procedures, before and during the intervention, using cardiac MRI.


  • DICOM Late Gadolinium Enhanced
  • Cardiac MRI data from various sources
  • 2D GRE and 3D NAV GRE
  • Inspection of DICOM attributes
  • Preview DICOM images without loading

3D viewer

  • Three ways to view the cardiac anatomy: 3D, 2D and 3D-sync-2D
  • 3D view of the left atrium to inspect the anatomy and identify the fibrotic areas
  • 2D view of the DICOM, simultaneously displaying 3 adjustable orthogonal planes
  • 3D-sync-2D: to understand MRI-to-3D Cardiac model correspondence

Study Storage Database

  • Storage and management of processed studies for later review
  • Search by patient name or ID, or Study name
  • Store multiple studies per patient
  • Exchange ADAS-VT studies between users


  • Import EP navigation Electro Anatomical Mapping (EAM) studies for comparison with the MRI ADAS study
  • Multi-window synchronized view for easy comparison between modalities (EAM, MRI…)
  • Quantification of tissue statistics
  • Possibility to segment left and right atria
* Under development, available soon

Tissue characterization

  • 3D Left Atrium Semiautomatic Segmentation
  • Automatic classification of tissue using selectable imaging thresholds
  • Automatic computation of IIR (Image Intensity Ratio)
  • EP-navigation friendly colour mappings to visualize tissue

Computation of parameters

  • Possibility to cut the atrial mesh to exclude areas from quantification or open the mitral orifice.
  • Automatic computation of atrial volume and Sphericity. *
* J Cardiovasc Electrophysiol. 2013 Jul;24(7):752-9


  • Help guide the ablation by exporting left atrial anatomy to formats compatible with EP navigation systems
  • Generation of snapshots in standard picture formats to keep a record and share the case


Visualize the shape and the fibrosis in 3D

Identify gaps in recurrent ablations

Export LA to formats accepted by navigation systems


ADAS 3D is developed in partnership with Hospital Clínic de Barcelona, Spain.

Hospital Clínic de Barcelona


ADAS-AF is being evaluated clinically in collaboration with:

Clinic, Barcelona, Spain. Dr. Lluis Mont, Director of the Arrhythmia Section • Herzzentrum Leipzig, Germany. Prof Gerhard Hindricks, Director of the Department of Electrophysiology • Hospital of the University of Pennsylvania, Philadelphia, USA. Prof Francis Marchlinski, Director of Electrophysiology Laboratory. Prof Saman Nazarian. Prof Harold Litt, Chief, Cardiovascular Imaging Section, Radiology • Barts Heart Centre, London, UK. Prof Richard Schilling, Director Cardiovascular CAG • CEDIMED, Medellin, Colombia. Dr Alejandro Zuluaga, Radiology • Hospital Universitario Virgen del Rocio, Seville, Spain. Dr Juan Acosta,Department of Cardiology • University Hospital Bonn, Germany. Dr. R Andrie • Hospital Germans Trias i Pujol. Dr. Felipe Bisbal Department of Prof Sonia Busch, Leitende Oberärztin für Elektrophysiologie

See also

ADAS-AF Product Characterize the tissue of the Left Atrium.

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