The technology

Based on the pre-intervention Late Gadolinium-enhanced MRI, the clinician examines the patient's images to decide on the best approach. ADAS-VT helps to translate the radiological images to interpret the VT substrate. The Left Ventricle (LV) myocardium is visualized by breaking it into easy-to-understand ‘layers’ to reveal the structure of the scar.

Layers

The layers can be explored interactively, and animations can be created to export into videos.

Channel detection

ADAS-VT analyzes the 3D structure of the myocardium and automatically detects border-zone corridors. These corridors or 'channels' have been found in the literature to be responsible for the re-entrant circuits that could be the source of the arrhythmia.

A screen shot of ADAS-VT showing the correspondence between a point in the 3D view and its position in the MRI.

Left: a 3D view of the LV 10% layer, with scar core volume (red) and border-zone (green-yellow). The detected channels are shown as white lines.

Right: the patient MRI, with a cross at the detected channel.

The detection method operates in a topological space which makes it suitable for either fast layer-based detection (detecting on a per-layer basis) or for in-depth 3D detection (detecting on the original volume) to account for transmural channels.

Left: MRI LV with Channels displayed in white.

Right: Electro-anatomical Map of the same patient showing voltage map and Late Potentials.

Image Courtesy of Dr Antonio Berruezo, Hospital Clínic de Barcelona, Spain

3D interaction

Interactive 3D view of the LV, with scar and detected channels (use your mouse to rotate with the left button, zoom in and out with the right button and change the colors using the drop-down list):

Partners

ADAS 3D is developed in partnership with Hospital Clínic de Barcelona, Spain.

Hospital Clínic de Barcelona

Collaborations

ADAS-VT is being evaluated clinically in collaboration with:

Herzzentrum Leipzig, Germany. Prof Gerhard Hindricks, Director of the Department of Electrophysiology • Johns Hopkins Hospital, Baltimore, USA. Prof Henry Halperin, Co-Director, Johns Hopkins Imaging Institute of Excellence • Cardiocentro Ticino, Lugano, Switzerland. Prof Angelo Auricchio, Director of the Heart Failure Program and Clinical Electrophysiology Unit • Hospital of the University of Pennsylvania, Philadelphia, USA. Prof Francis Marchlinski, Director of Electrophysiology Laboratory. Prof Saman Nazarian. Prof Harold Litt, Chief, Cardiovascular Imaging Section, Radiology • INCOR, Sao Paulo, Brazil. Prof Mauricio Scanavacca, Diretor da Unidade Clinica de Arrritmia e Marcapasso • National University Hospital, Singapore. Dr Pipin Kojodjojo, Department of Cardiology • Guglielmo da Saliceto Hospital, Piacenza, Italy. Dr Diego Penela, Department of Cardiology • CEDIMED, Medellin, Colombia. Dr Alejandro Zuluaga, Radiology • St Antonius Ziekenhuis, Nieuwegein, The Netherlands. Prof Lucas Boersma, Head of Cardiology • Coburg Herzzentrum, Germany. Prof Sonia Busch, Leitende Oberärztin für Elektrophysiologie • Hospital Universitario Virgen del Rocio, Seville, Spain. Dr Juan Acosta,Department of Cardiology • Barts Heart Centre, London, UK. Prof Richard Schilling, Director Cardiovascular CAG

See also

ADAS-VT Technology Visualize the inside of the myocardium in 3D.

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